23 A6 biendl.indd
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POSSIBILITIES FOR USE IN MEDICINE | The xanthohumol hop component in particular has been a focus of interest for some time. It has an extraordinarily wide spectrum of pharmacologically positive action, above all highly promising cancer chemo-preventive potential. The compound 8-prenylnaringenine found in hops in traces only is also becoming increasingly important due to its estrogenic properties.
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Expression of the a7b1 Laminin Receptor Suppresses Melanoma Growth and Metastatic Potential
The a7b1 integrin is a laminin-binding receptor that was originally identified in melanoma. Here, we show that, in clonally derived mouse K1735 melanoma variant cell lines with high (M-2) and low (C-23) metastatic potential, elevated expression of a7 correlates with reduced cell motility, metastasis, and tumor growth. Both cell lines showed similar b1 integrin-dependent adhesion to laminin-1 an...
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Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011-2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circu...
متن کاملAtypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker.
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a De...
متن کاملMonoclonal antibodies as probes of epithelial membrane polarization
Monoclonal antibodies directed against antigens in the apical plasma membrane of the toad kidney epithelial cell line A6 were produced to probe the phenomena that underlie the genesis and maintenance of epithelial polarity. Two of these antibodies, 17D7 and 18C3, were selected for detailed study here. 17D7 is directed against a 23-kD peptide found on both the apical and basolateral surfaces of ...
متن کاملA T-shaped amphiphilic molecule forms closed vesicles in water and bicelles in mixtures with a membrane lipid.
The T-shaped amphiphilic molecule A6/6 forms a columnar hexagonal liquid-crystalline phase between the crystalline and the isotropic liquid when studied in bulk (Chen et al., 2005). Because of the hydrophilic and flexible oligo(oxyethylene) side chain terminated by a 1-acylamino-1-deoxy-d-sorbitol moiety attached to a rigid terphenyl core with terminal hexyloxy alkyl chains, it was expected tha...
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